The HOPE method is a research proposal to create models that can be used to decode the mRNA of a protein whose gene is not known based on input data of protein structure. Link https://www.mdbiomimicry.com/post/the-hope-method-monoclonal-antibodies-and-bio-proteins-a-game-changer-in-antibody-engineering-and-p
Once the mRNA of a protein is known proceed in one of two ways.
Scientists can identify the gene within the species genome by looking for the same split exon sequences in the DNA (remember DNA contains introns and exons thus why the mRNA which only codes for the genes exons would appear to be split up within the DNA as well as DNA will have a missing hydroxyl group within their nucleic acids and Thymine while RNA has Uracil). Using AI algorithms identify where similar DNA sequences of these split exons appear in the genome and test for the protein's gene within that region.
Scientists can also try a different approach in recombinant DNA technology, by not using the protein's gene within the plasmid and using synthetic DNA instead coding for IVT mRNA that would direct the bacterial or yeast ribosomes to produce the bio protein of interest. Which to my knowledge has not been attempted as of yet.